Shaomeng wang group umichigan
WebbShaomeng Wang Crizotinib is the first anaplastic lymphoma kinase (ALK) inhibitor to have been approved for the treatment of non–small cell lung cancer (NSCLC) harboring an … WebbDr. Wang was named the Warner-Lambert/Parke-Davis Professor in Medicine in 2007. Dr. Wang serves as the Co-Director of the Molecular Therapeutics Program at the University …
Shaomeng wang group umichigan
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WebbAntitumor activity of APG-2449 was evaluated in mice bearing subcutaneous tumors derived from H3122 NSCLC cells carrying EML4-ALK fusion gene (A; treated for 3 weeks, n = 7 per treatment group; T/C values were assessed on Day 21), KARPAS-299 cells carrying NPM-ALK fusion gene (B; treated for 3 weeks, n = 7 per treatment group; T/C values were … WebbAfter spending one year as a Postdoctoral Research Fellow at Purdue University, USA, he joined the Wang Lab in 2016. Currently focused on the development of novel small molecule inhibitors (EED/LSD1) and drug-like properties for optimization of PROTACs. Lingying Yeng Research Fellow [email protected] Ph.D. Sichuan University, China …
Webb7 sep. 2024 · A highly efficient strategy for remote reductive cross-electrophile coupling has been developed through the ligand-controlled nickel migration/arylation. This general protocol allows the use of abundant and bench-stable alkyl bromides and aryl bromides for the synthesis of a wide range of structurally diverse 1,1-diarylalkanes in excellent yields … Webb18 feb. 2024 · Since 2002, he has submitted 111 inventions to U-M’s Office of Technology Transfer, executed 63 commercialization agreements, and founded five startups. His …
WebbAfter spending one year as a Postdoctoral Research Fellow at Purdue University, USA, he joined the Wang Lab in 2016. Currently focused on the development of novel small … WebbThe natural product-like compound 1 was identified as a direct inhibitor of the menin–MLL interaction by in silico screening. Structure-based optimization furnished analogue 1a, which showed significantly higher potency than both the lead structure 1 and the reference compound MI-2.
Webb13 dec. 2024 · Shaomeng Wang and Gunda I. Georg J. Med. Chem.2012,55,1,1-1 Publication Date(Web):December 22, 2011 Full Text PDF Synthesis of biologically active taxol analogs with modified phenylisoserine side chains Gunda I. Georg, Zacharia S. Cheruvallath, Richard H. Himes, Magdalena R. Mejillano, and Charles T. Burke J. Med. …
Webb1 nov. 2024 · Guo G, Li X, Wang Q, Li Y, Chu H, Ma Q, Tu J, Zhang D. IEEE Trans Ultrason Ferroelectr Freq Control, 68(4):1399-1407, 26 Mar 2024 Cited by: 0 articles PMID: 33108285. Polarization-Encrypted Orbital Angular Momentum ... Europe PMC is a service of the Europe PMC Funders' Group, ... cs go aimbot cfgWebbAdministrative Assistant, Senior . [email protected]. Nicholas VanDyke. Lab Manager. [email protected] csgo aimbot dllWebb11 nov. 2024 · Based on our previous STAT3 SH2 domain inhibitor CJ-887 (compound 1) (Chen et al., 2010a), we have performed extensive optimization, as summarized in Figure 1 A, to obtain potent and cell-permeable STAT3 inhibitors.First, we designed compound 2 by cyclization of the amino group with the phenyl group to form an indole, which binds to … cs go agentenWebbShaomeng Wang's lab University of Michigan (U-M) Overview Advance your research research projects Featured research (4) Discovery of Potent Small-Molecule Inhibitors of MLL Methyltransferase... e36 clutch lineWebb15 maj 2013 · Our study has led to the identification of a set of highly potent MDM2 inhibitors with a stereochemistry that is different from that of our previously reported compounds. The most potent compound (MI-888) binds to MDM2 with a Ki value of 0.44 nM and achieves complete and long-lasting tumor regression in an animal model of … e36 clutch master cylinder diyWebbFormer Group Members _____ Name Current (or last ... (Prof. Shaomeng Wang) Jeremy Fournier Scientist, Arcus Biosciences, Hayward, CA. Kyle Young Scientist, Boehringer Ingelheim, Germany. Joseph Alvarado ... e36 clutch master cylinder rebuild kitWebbTo accomplish our goals of discovering highly optimized compounds suitable for clinical development and rapidly advancing them into clinical development, Dr. Wang ha s established extensive collaborations with basic scientists, translational scientists and clinical investigators at UMCCC and in other institutions. cs go aimbot code