P-selectin antibody patent
WebJan 18, 2024 · Models of ischaemia–reperfusion injury, in particular, produced impressive results: a P-selectin blocking antibody reduced tissue necrosis by up to 90% after … WebJun 1, 2024 · Introduction: Previously, in a murine model of blunt thoracic trauma, we provided evidence of primary pulmonary thrombosis associated with increased expression of the cell adhesion molecule, P-selectin. In this study, mice are treated with P-selectin blocking antibody after injury to investigate the clinical viability of this antibody for the …
P-selectin antibody patent
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WebCompounds, compositions, and methods for treating and/or preventing at least one disease, disorder, and/or condition N associated with E-selectin, galectin-3, and/or CXCR4 chemoki WebMarkers of platelet membrane proteins were identified using antibodies against CD47 and P-selectin. 2.4. Encapsulation Efficiency [email protected] was subjected to centrifuge at 20,000× g for 40 min to separate the free CCM from the encapsulated drug. The amount of free CCM in the supernatant was determined spectrophotometrically at 426 nm.
WebAntibodies are disclosed which bind specifically to P-selectin and which block the binding of PSGL-1 to P-selectin. These anti-P-selectin antibodies may also cause dissociation of … WebNov 29, 2024 · The Platelet Factor-4 (PF4)-Dependent p-Selectin Expression Assay (PEA) Is Highly Accurate for the Detection of Pathogenic HIT Antibodies: Results of a 440-Sample Prospective Blinded Study Blood American Society of Hematology 331. Pathophysiology of Thrombosis: Risk Factors and Thromboembolism November 29, 2024
WebJan 18, 2002 · Compounds that bind to P-Selectin Glycoprotein 1 (PSGL-1) on the surface of T cells or natural killer (NK) cells can be used to induce T cell or NK cell depletion and/or to induce T cell or NK cell apoptosis. The compounds and methods of the invention can be used to control unwanted T cell- or NK cell-mediated immune responses in conditions … WebNational Center for Biotechnology Information
WebThis invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do …
WebCompounds that are synthetically inexpensive to make relative to the naturally occurring selectin ligands and that retain selectin binding activity are described that have a three-dimensionally stable configuration for sialic acid and fucose, or analogs or derivatives of these groups, such that sialic acid and fucose are separated by a linker that permits … m7 cliff\u0027sWebMar 23, 2024 · 1. Delivered a preclinical candidate for inflammation (US Patent 2014039308 - issued) This work was published in Nature (doi: … m7 bridgehead\u0027sWebWestern Blot analysis of P-Selectin (CD62P) in various cell lines using a P-Selectin (CD62P) Polyclonal antibody ( Product # PA5-120169) at a dilution of 1:1,000. 25 µg of lysate or protein were loaded into each lane. A blocking buffer of 3% nonfat dry milk in TBST was used. An HRP conjugated Goat Anti-Rabbit IgG (H+L) secondary antibody was ... kit cars historyWebP-Selectin Antibody (CTB201) is an IgG 1 κ mouse monoclonal P-Selectin antibody (also designated CD62 antibody, SELP antibody, selectin P antibody) suitable for the detection of the P-Selectin protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and FCM. P-Selectin Antibody (CTB201) is available as both the non-conjugated anti-P-Selectin … m7 cipher\\u0027sWebThe RB40.34 monoclonal antibody specifically binds to mouse P-selectin (CD62P), a 140 kDa protein which is expressed ... P-selectin, but not P-selectin glycoprotein ligand 1. Blood. 2002; 99(3):946-956. ... BD Biosciences will not be held responsible for a patent infringement or other violations that may occur with the use of our products ... kit car shows 2021WebCD62P is a 140 kD type I transmembrane glycoprotein also known as P-selectin, platelet activation-dependent granule membrane protein (PADGEM), and GMP-140. It is expressed … kit car showsWebHuman monoclonal anti-E-selectin antibodies may be generated by any number of techniques with which those having ordinary skill in the art ... :866-74 (2009)). We demonstrated that a glycomimetic compound dual inhibitor of E-selectin and CXCR4 (see U.S. Patent Application Publication No. 2010/0279965) mobilized human AML engrafted … m7 buff\u0027s